Physician-Scientist · Thru-Hiker · Advocate

Dr. Kristen Hege

Thirty years advancing cancer medicine.
2,650 miles on the Pacific Crest Trail.

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Dr. Kristen Hege

A Life at the Intersection of Science and Adventure

Dr. Hege is a highly regarded physician-scientist with 30 years of experience in biopharma drug development and academic clinical medicine. She currently serves on the Board of Directors of EvolveImmune and KSQ Therapeutics, and recently stepped down from director roles at Kelonia, Mersana, and Adaptimmune following external acquisitions.

In addition, she serves as co-chair of the Biotech Committee, Spring Scientific Summit, and Women in Immunotherapy Network for the Society for the Immunotherapy of Cancer (SITC), along with advisory roles at cTRL, Moonlight, Dispatch, Neomorph, Kamau, Cartography, Shennon, Avemi, OverT, Waypoint, Moderna, Legend, Infinitopes, Generate, and Merck.

Dr. Hege retired from her executive role at Bristol Myers Squibb in 2023 to pursue her lifelong dream of thru-hiking the 2,650-mile Pacific Crest Trail. In her BMS role as SVP Early Clinical Development, Hematology, Oncology & Cell Therapy, she was responsible for advancing a pipeline of small molecules, biologics, and cell therapies from first-in-human studies through clinical proof-of-concept. While there she led the 2Seventybio (formerly bluebird)-partnered BCMA CAR-T cell program (Abecma) in multiple myeloma from inception through FDA approval.

Prior to BMS she held a similar role at Celgene as well as executive R&D roles in biotech at Cell Genesys, Cellerant, and Theraclone. In addition, Dr. Hege spent nearly three decades as part-time clinical faculty in hematology at the University of California, San Francisco (UCSF), most recently as Clinical Professor of Medicine.

Dr. Hege has received numerous accolades including recognition by Forbes magazine as one of “50 Women Over 50: Entrepreneurs”, by UCSD with the Duane Roth Career Achievement Award for advances in science and medicine, and most recently with election as a Fellow of the Academy of Immuno-Oncology by the Society for the Immunotherapy of Cancer (SITC). She is passionate about advocacy for the advancement of women in science and medicine and has turned her PCT adventure into a fundraiser supporting leadership skills development for early-career women working in the field of cell and gene therapy.

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Career & Affiliations

Writing & Interviews

Interview

Conversation with Dr. Jennifer Grandis, Author of “Harsh Medicine”

An interview with a colleague on breaking down barriers to the advancement of women in science and medicine — lessons from the PCT applied to professional leadership.

Watch on LinkedIn →
Essay Series

Lessons Learned from Hiking the PCT

A 6-part series in Endpoint News exploring the surprising parallels between thru-hiking the Pacific Crest Trail and 30 years on the frontier of cancer drug development and leadership.

Read on Endpoint News →
Feature

A Mountain Climb to Benefit Immunotherapy Research

Penn Medicine Magazine on how a PCT thru-hike honoring her mother — the only woman to graduate from Penn Medicine’s class of 1953 — became a fundraiser for immunotherapy research.

Read at Penn Medicine →
Cover Story

Hefty Snowpack Doesn’t Deter Oregon Hiking Couples’ Pacific Crest Trail Plans

The Bend Bulletin’s 2023 cover story on Dr. Hege and her husband setting out to thru-hike the Pacific Crest Trail despite a historically heavy Sierra snowpack.

Read at Bend Bulletin →
Profile

Meet Dr. Kristen Hege

The Female Scientist profiles a physician-scientist inspiring the next generation of women in medicine to draw strength from nature and time in the wilderness.

Read on The Female Scientist →
Article

Backpacking Through the Pandemic

On leading wilderness retreats for college interns at Celgene and Bristol Myers Squibb — using backpacking as a forum for building confidence, resilience, and leadership skills.

Read on BizWomen →
Video

Benchling Fireside Chat: Reflections on Career and the COVID Pandemic

A fireside chat reflecting on a 30-year career in cancer drug development and leadership, and on navigating clinical research and drug development through the COVID-19 pandemic.

Watch on YouTube →
Essay

Lessons Learned from Misadventure

A wide-ranging reflection on a 30-year career in cancer drug development and the lessons in resilience, humility, and leadership drawn from misadventures in the wilderness.

Read the Essay →
Journal Feature

Turning Points

Nature Medicine’s “Turning Points” column, in which Dr. Hege reflects on a defining moment in her career at the frontier of cancer immunotherapy.

Read in Nature Medicine →

Projects

Women Go Wild — PCT Documentary
Coming Fall 2026
Documentary Film

Women Go Wild

A documentary film following Dr. Hege’s 2,650-mile Pacific Crest Trail adventure and the fundraising effort it inspired — supporting leadership development for early-career women in cell and gene therapy. Premiering Fall 2026.

Dr. Kristen Hege in The Greatest Save — ESPN Documentary
Documentary Film

The Greatest Save

An ESPN documentary chronicling former U.S. national team goalkeeper Kasey Keller’s 16-year battle with lymphoma and 5-year remission following treatment with CD19 CAR T-cell therapy (Breyanzi). Dr. Hege is interviewed as a blood cancer and CAR-T expert.

Dr. Kristen Hege backpacking on the Pacific Crest Trail
Fundraiser

PCT Fundraiser for Women in Cell & Gene Therapy

Dr. Hege’s PCT thru-hike became a fundraiser supporting leadership development for early-career women in cell and gene therapy — honoring her mother, the only woman to graduate from Penn Medicine’s class of 1953.

Visit Fundraiser Page

Leadership (and Life) Lessons from the Pacific Crest Trail

Kristen Hege retired from her biopharma executive role at Bristol Myers Squibb (BMS) and her academic hematology practice at UC San Francisco in 2023 to pursue her lifelong dream of thru-hiking the 2,650-mile Pacific Crest Trail from Mexico to Canada with her husband.

In this unique presentation, she reflects on her pioneering 30-year history with research and development of CAR T-cell immunotherapy for cancer, from the dawn of this breakthrough field at Cell Genesys, a startup Bay Area biotech company in the 1990s, to Celgene, and ultimately BMS. A career highlight was overseeing the development of Abecma, the first BCMA-targeted CAR T-cell treatment for multiple myeloma, a program she led from target identification to FDA approval.

She also shares her Pacific Crest Trail story and reflections on leadership lessons learned from this grand adventure that resonate with all who pursue high-risk endeavors in science and medicine. Finally, she reflects on her efforts to turn her PCT hike into a philanthropic effort to support and advance the next generation of women physicians and scientists working in cancer immunotherapy. This fundraising initiative is named in honor of her mother, a pioneering physician who was the only woman to graduate from her medical school class at the University of Pennsylvania in 1953.

Visit Fundraiser Page
Dr. Kristen Hege

Venues

2024

  • Bristol Myers Squibb (Seattle)
  • Bristol Myers Squibb (Sierra Point)
  • Mission Bay Capital Biolabs
  • UCSF Gladstone Institute
  • Rockside Ranch
  • cTRL Therapeutics
  • Mersana Therapeutics
  • Kelonia Therapeutics
  • Dragonfly Therapeutics
  • Flagship Pioneering
  • Third Rock Ventures
  • SITC Women’s Leadership Conference
  • SITC Staff Retreat
  • Adaptimmune
  • Dispatch Bio
  • B+ Biolabs & Fitler Club
  • Terns Pharmaceuticals

2025

  • UCSF International Women’s Day
  • Genentech
  • Cartography Biosciences
  • KSQ Therapeutics
  • Scripps Clinic Grand Rounds
  • Scripps Research Translational Institute
  • Neomorph, Inc.
  • Broad Institute Symposium
  • Cellicon Valley Symposium
  • Clasp Therapeutics
  • New Horizons in Immunotherapy of Cancer Symposium
  • BrightEdge Entrepreneurs Pitch Event
  • Women Who Explore
  • Janux Therapeutics

2026

  • Phacilitate Women in Advanced Therapies Week
  • Women in the Enterprise of Science and Technology (WEST) (planned)
  • Prostate Cancer Foundation (planned)
  • Gladstone Institute, UCSF (planned)
  • Azalea Therapeutics (planned)

For speaking inquiries, reach out at kristen.hege@gmail.com.

Let’s Connect

For board inquiries, speaking engagements, media requests, or to learn more about Dr. Hege’s work, connect on LinkedIn.

View LinkedIn Profile